Tirzepatide dosage: chart, schedule, and mg to units conversion

The standard titration ladder, the full milligram to unit conversion for U-100 syringes, missed dose rules, and how to tell when a dose is not agreeing with you.
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Medically reviewed by a licensed US practitioner. Last updated September 2026.
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Two different things get called "the dose".

Tirzepatide is prescribed as a once-weekly injection and is almost always started low and increased in steps. The confusion starts because two different numbers get called the dose: the milligram dose your prescriber writes, and the number of units you draw on a syringe. They are not the same number, and the unit number changes depending on how concentrated your vial is.

This page covers the standard titration schedule, the full milligram to unit conversion for U-100 insulin syringes, what to do when you miss a dose, and how to tell when a dose is too high.

Your prescriber sets your dose. Use this page to understand what you were prescribed, never to choose or change a dose yourself.
Every unit figure on this page is keyed to a concentration. Society does not publish a  standard vial concentration, and there is no default that will be right for you. The only number that applies to your draw is the concentration printed on the vial in your hand.
Key takeaways

The seven things worth knowing before you read further.

Tirzepatide is dosed once weekly, starting at 2.5mg. It is increased in 2.5mg steps no sooner than every 4 weeks. The dose ladder is 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg.

The maximum dose is 15mg once weekly.
That applies to Zepbound® and Mounjaro® as well. There is no approved dose above 15mg.

To convert milligrams to syringe units: units = (dose in mg ÷ vial concentration in mg/mL) × 100. That applies to a standard U-100 insulin syringe, where 100 units is 1 mL.

2.5mg of tirzepatide is 25 units from a 10 mg/mL vial, 50 units from a 5 mg/mL vial and 12.5 units from a 20 mg/mL vial. There is no single unit answer without a concentration.

20 units of tirzepatide is 2mg from a 10 mg/mL vial, 1mg from a 5 mg/mL vial and 4mg from a 20 mg/mL vial. A unit number on its own does not identify a dose.

Brand pens do not use units at all. Zepbound® and Mounjaro® single-dose pens deliver a fixed milligram dose in 0.5 mL, so there is nothing to measure. Society does not offer Zepbound.

If you miss a dose, take it within 4 days. After 4 days, skip it and resume your normal weekly schedule.
The ladder

Tirzepatide dosage chart for weight loss.

Tirzepatide starts at 2.5mg once weekly. That first dose is a tolerance-building dose rather than a treatment dose: it exists to let your digestive system adjust before the dose that does the work. After 4 weeks the dose typically increases to 5mg, and from there it can be raised in 2.5mg steps, each after at least 4 weeks at the current dose.
Week
Weekly dose
Purpose
Weeks 1 to 4
2.5mg
Starting dose. Builds tolerance. Not intended as a maintenance dose.
Weeks 5 to 8
5mg
First maintenance-level dose. Many people respond well here and stay.
Weeks 9 to 12
7.5mg
Titration step between 5mg and 10mg, for a gentler increase.
Weeks 13 to 16
10mg
Maintenance dose.
Weeks 17 to 20
12.5mg
Titration step between 10mg and 15mg.
Week 21 onward
15mg
Maximum approved dose. There is nothing above this.
It is a schedule, not a staircase you have to climb. 5mg, 10mg and 15mg are the recommended maintenance doses. 7.5mg and 12.5mg exist as stepping stones for people who need a gentler increase. Plenty of people stay at 5mg or 10mg indefinitely because it is working and they tolerate it.

Four weeks is a minimum, not a deadline. If you are still having nausea at the end of week 4, staying where you are for another few weeks is a normal clinical decision, not a setback.

Your prescriber can move slower than this chart. Extended titration, holding a dose, or stepping back down a level are all standard responses to side effects. None of them means starting over.
The part most dosage pages skip

Tirzepatide dosage in units: the full mg to units conversion.

If you were prescribed tirzepatide as a multi-dose vial rather than a pre-filled pen, your prescription is written in milligrams and your syringe is marked in units. You have to convert. The conversion is not fixed, because vials are filled at different concentrations.
Units = (dose in mg ÷ vial concentration in mg/mL) × 100. The multiplication by 100 comes from the syringe. A U-100 insulin syringe is marked so that 100 units equals 1 mL, which makes 50 units 0.5 mL and 25 units 0.25 mL. The syringe measures volume. It knows nothing about the drug inside it. To go the other way: dose in mg = (units ÷ 100) × concentration in mg/mL.
Your vial's concentration is printed on the label, usually as a total milligram amount and a total volume, for example "20 mg/2 mL". That is 10 mg/mL. If the label gives you only a total and a volume, divide the milligrams by the millilitres to get the concentration.

The four concentrations below are common fill strengths, listed so you can find the one that matches your label. Read down the column for the concentration printed on your own vial, not the column someone quoted to you in a forum.
Dose
2.5mg
5mg
7.5mg
10mg
12.5mg
15mg
Doses that fit one 1 mL syringe
At 2.5 mg/mL
100 units (1.0 mL)
200 units (2.0 mL)
300 units (3.0 mL)
400 units (4.0 mL)
500 units (5.0 mL)
600 units (6.0 mL)
2.5mg only
At 5 mg/mL
50 units (0.5 mL)
100 units (1.0 mL)
150 units (1.5 mL)
200 units (2.0 mL)
250 units (2.5 mL)
300 units (3.0 mL)
Up to 5mg
At 10 mg/mL
25 units (0.25 mL)
50 units (0.5 mL)
75 units (0.75 mL)
100 units (1.0 mL)
125 units (1.25 mL)
150 units (1.5 mL)
Up to 10mg
At 10 mg/mL
12.5 units (0.125 mL)
25 units (0.25 mL)
37.5 units (0.375 mL)
50 units (0.5 mL)
62.5 units (0.625 mL)
75 units (0.75 mL)
All of 2.5mg to 15mg
A 20 mg/mL vial is the only concentration in this table that covers the whole 2.5mg to 15mg ladder inside one 1 mL syringe. That is why higher-concentration vials are common for people further along in titration. It is an observation about arithmetic, not a statement about what Society dispenses. Check your own label.
Anything above 100 units does not fit in a single 1 mL syringe. Those cells are in the table for completeness, but in practice they signal a mismatch. A 2.5 mg/mL vial is not a sensible way to deliver 10mg, and if your arithmetic lands above 100 units, the likeliest explanation is that you have the wrong concentration, not that you need two syringes. Stop and confirm with your care team before drawing anything.
Straight answers

How many units is 2.5mg of tirzepatide?

It depends entirely on your vial, and anyone who gives you one number without asking about concentration is guessing. From a 10 mg/mL vial, 2.5mg is 25 units. From a 5 mg/mL vial it is 50 units. From a 20 mg/mL vial it is 12.5 units. From a 2.5 mg/mL vial it is 100 units, a full syringe.
Vial concentration
2.5 mg/mL
5 mg/mL
10 mg/mL
20 mg/mL
Units for 2.5mg
100 units
50 units
25 units
12.5 units
Volume
1.0 mL
0.5 mL
0.25 mL
0.125 mL
The arithmetic
2.5 ÷ 2.5 = 1.0 mL, × 100 = 100 units
2.5 ÷ 5 = 0.5 mL, × 100 = 50 units
2.5 ÷ 10 = 0.25 mL, × 100 = 25 units
2.5 ÷ 20 = 0.125 mL, × 100 = 12.5 units
10 mg/mL is a common compounded concentration, which is why 25 units is the answer repeated most often online. It is not the only correct one and it may not be yours. Check your label every time you start a new vial, because a refill can arrive at a different concentration than the one before it, and the unit number changes with it even though your prescribed dose has not.

How many mg is 20 units of tirzepatide?

Twenty units is always 0.2 mL. What that 0.2 mL contains is the part that changes. From a 10 mg/mL vial, 20 units is 2mg. From a 5 mg/mL vial it is 1mg, and from a 20 mg/mL vial it is 4mg. The formula is mg = (units ÷ 100) × concentration.
Vial concentration
2.5 mg/mL
5 mg/mL
10 mg/mL
20 mg/mL
Dose in 20 units
0.5mg
1mg
2mg
4mg
The arithmetic
(20 ÷ 100) × 2.5 = 0.5mg
(20 ÷ 100) × 5 = 1mg
(20 ÷ 100) × 10 = 2mg
(20 ÷ 100) × 20 = 4mg
This is the single most important thing on this page: a unit number is meaningless without a concentration. If someone in a forum says they take 30 units, that tells you nothing about their milligram dose. Never copy another person's unit number.

If you would rather not do the arithmetic by hand, our GLP-1 dose calculator converts a prescribed milligram dose into units once you enter your vial's concentration. Treat the result as a way to check what is on your prescription label, not as a second opinion on your dose.
Powder vials

If your vial came as a powder.

Some vials are supplied as a lyophilized powder that has to be reconstituted with bacteriostatic water before use. In that case the concentration is created at reconstitution, and it depends on how much diluent goes in. Concentration in mg/mL equals the total milligrams in the vial divided by the millilitres of diluent added.
Vial contents
10mg
10mg
20mg
20mg
30mg
30mg
40mg
Diluent added
1.0 mL
2.0 mL
1.0 mL
2.0 mL
1.5 mL
3.0 mL
2.0 mL
Resulting concentration
10 mg/mL
5 mg/mL
20 mg/mL
10 mg/mL
20 mg/mL
10 mg/mL
20 mg/mL
2.5mg dose
25 units
50 units
12.5 units
25 units
12.5 units
25 units
12.5 units
5mg dose
50 units
100 units
25 units
50 units
25 units
50 units
25 units
Add a different volume of diluent and every unit number changes. That is why reconstitution instructions come from the pharmacy that dispensed your vial, and why you follow the exact diluent volume on your paperwork rather than a volume you found online. If your vial arrives already in liquid form, none of this applies: the concentration is set and printed on the label.

Concentrations vary between pharmacies. Brand tirzepatide has one standardized presentation. Compounded vials do not. One pharmacy's 2.5mg dose might be 25 units and another's 12.5 units, for the identical prescription. That is not an error, it is a different fill concentration, and it is the biggest single source of dosing confusion among people who switch pharmacies or compare notes with a friend.

Brand pens skip all of this. Zepbound® and Mounjaro® single-dose pens contain a fixed milligram dose in 0.5 mL. There is no drawing, no measuring and no unit conversion. You use the whole pen. Society offers injectable GLP-1 medication only and does not offer Zepbound.
Missed doses

What to do if you miss a dose.

Missing a dose is common and usually straightforward to correct. The rule is based on how many days have passed.
Time since the missed dose
Less than 4 days (96 hours)
More than 4 days
20 mg/mL
What to do
Take the missed dose as soon as you remember
Skip the missed dose entirely. Do not double up
Do not restart at your previous dose. Contact your care team
Next dose
Return to your normal weekly day
Take your next dose on your normal weekly day
Your prescriber may restart you lower and re-titrate
Two things to avoid. Do not take two doses close together to catch up, because that raises the risk of nausea and vomiting without adding benefit. And do not restart at your old dose after a long gap: tolerance fades, and a dose you handled comfortably two months ago can hit very differently now.

Changing your injection day. You can move your weekly day. The requirement is spacing: leave at least 3 days (72 hours) between two injections. If you normally inject on a Monday and want Thursday, take the Monday dose as usual and the next one on Thursday of that same week or later. Moving from Monday to Tuesday would put two doses one day apart, so you would take the Monday dose and begin the new Tuesday schedule the following week. Once you have moved, stay on the new day.
Tolerability

Signs your dose is too high.

Some digestive side effects are expected in the first weeks at a new dose and usually ease as you adjust. The signal worth acting on is side effects that are severe, that are not improving, or that are stopping you eating and drinking normally.
What you notice
Vomiting that keeps you from holding down fluids, or dark urine, dizziness on standing, passing very little urine
Nausea that has not improved after two to three weeks at the same dose
Severe or persistent abdominal pain, particularly upper abdominal pain that radiates to your back
Constipation lasting more than a few days, or an inability to pass gas or stool
A resting heart rate that feels consistently elevated, or new palpitations
Difficulty eating enough to maintain muscle and adequate nutrition
Why it matters
Signs of dehydration. Call your care team the same day
Usually a reason to hold the dose rather than increase it
Needs prompt medical attention, not a wait-and-see
Worth a call before it becomes an obstruction question
Report it rather than assume it will settle
A reason to review the dose and your intake with your provider
Slowing down is a normal clinical option. Holding your current dose for longer, or moving back to the previous dose and re-titrating more gradually, is a routine adjustment. Neither is a failure, and neither means the medication is not right for you. Seek emergency care for severe, unrelenting abdominal pain, repeated vomiting you cannot control, or signs of an allergic reaction such as swelling of the face, lips or throat, or difficulty breathing.
Dose and results

How dose relates to results.

In SURMOUNT-1, the 72-week trial of tirzepatide for weight management in adults with obesity or overweight without diabetes (Jastreboff and colleagues, New England Journal of Medicine, 2022), average weight reduction was greater in the higher maintenance dose groups: approximately 15.0% at 5mg, 19.5% at 10mg and 20.9% at 15mg, against approximately 3.1% with placebo.

Read that carefully, because it is easy to over-read. Those are group averages from a controlled trial, measured alongside lifestyle intervention over 72 weeks. They describe what happened on average to a study population. They are not a prediction for any individual and they are not a result to expect. Individual outcomes varied widely within every dose group, including people who lost considerably less than the average.

There is also a trade-off the averages hide: higher doses were associated with more gastrointestinal side effects. The most effective dose for you is not automatically the highest one. It is the lowest dose that gets you a result you can sustain, because a dose you stop taking produces nothing. This is a conversation to have with your prescriber at each titration point, not a target to chase on your own.
Questions

Tirzepatide dosage questions.

Important safety information
GLP-1 based treatments may carry risks, including the potential for thyroid C-cell tumors. These medications should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Side effects may include nausea, headaches or dizziness, fatigue or changes in appetite, gastrointestinal discomfort, and injection-site reactions.

Compounded medications are not FDA-approved and have not been evaluated by the Food and Drug Administration for safety, efficacy, or quality.

Talk to a prescriber about your dose.

Every number on this page is general information. Your dose, your titration pace and your vial concentration are set by the clinician who prescribes for you, and those instructions take priority over any chart, calculator or forum post. Society is 100% online, and getting started takes a free 2-minute evaluation. Most members hear back from a provider within a day or two, medication is dispensed through US licensed pharmacies, and delivery is free, discreet and takes 1 to 2 days. No insurance is required. Tirzepatide starts from $249 per month. You can pause, switch or cancel anytime, which stops future billing cycles, and the first two months of any treatment plan are non-refundable.
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GLP-1–based treatments may carry risks, including the potential for thyroid C-cell tumors. These medications should not be used by individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Please consult a healthcare provider for complete prescribing and safety information.
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